Advances of civilization, scientific and technical progress and achievements in medicine have not help to reduce the incidence of infectious and non-infectious diseases among the populations of the planet. On the contrary, the number of oncological, cardiovascular, respiratory and endocrine diseases and neuropsychiatric disorders is growing.

A new group of so-called emerging infections, including AIDS, parenteral types of hepatitis and others have appeared. The Earth’s population experienced a decrease in general resistance due to globally unfavorable social (malnutrition), ecological (the atmosphere and the environment pollution with many from modern technology) and medical (unjustified use of some medicines, narcotics, alcohol, stress and so on) factors that are some of the causes of the existing situation. All of these factors are pernicious to the immune system and can cause immunodeficiency.

The use of immune modulators is one of the principal means in maintaining normal immune system function and in restoring immunity in immunodeficient conditions. Immune modulators both natural and synthetic are capable of stimulating or suppressing the immune system.

A multitude of immune modulators are used in medical practice but their effectiveness and other properties defining their safety, simplicity in use and economy factors differ greatly (A.A. Vorobiev, RAMS Bulletin, #4, 2002). Natural, endogenous immune modulators, which contain basic substances that take part in the processes of immune regulation are the most acceptable and adequate for humans. Being composed of natural peptides obtained from cow colostrum Transfer Factor is considered to be one such immune modulators. The main functions of these peptides in the body is to provide immune protection against microbes (bacteria, viruses, fungi, protozoa), cancerous cells and other antigens capable of disturbing vital processes in the body.

Transfer Factors stimulate the cellular arm of the immune system (killer lymphocytes in particular), activate immunocytokine synthesis and regulate immune functions.

Transfer Factor is superior to other, even wll know immune modulators being extremely effective in boosting the immune system. It possesses a broad spectrum of action, is safe, is used orally as gelatinous capsules, has no contraindications, causes no adverse reactions and is effective both in adults and children.

Transfer Factor has been successfully used for many years for the treatment and prevention of bacterial, viral, fungal infections, parasitic diseases, malignant tumors, autoimmune conditions, neurasthenic, allergic and endocrine disorder, primary and secondary immunodeficiencies and in diseases accompanied by disturbances in immune functions.

Transfer Factors and Transfer Factors Plus products have been extensively studied in Russian clinics and research institutions. This helped to generalize clinical results into the form of methodological recommendations. This methedological letter is meant to acquaint physicians, medical students, clinical residents and post graduate with current information, concerning the mechanisms of the immune system response to exogenous factors of viral and bacterial origin, with the properties of Transfer Factor products and the result of the studies aimed at the evaluation of their effectiveness in various pathological conditions.